MovDisordV3, Main, Exploration, bibRecord, 004638

Bilateral subthalamic nucleus stimulation and quality of life in advanced Parkinson's disease

Identifieur interne : 004638 ( Main/Exploration ); précédent : 004637; suivant : 004639

Bilateral subthalamic nucleus stimulation and quality of life in advanced Parkinson's disease

Auteurs : Pablo Martinez-Martin [Espagne] ; Francesc Valldeoriola [Espagne] ; Eduardo Tolosa [Espagne] ; Manuela Pilleri [Espagne] ; José Luis Molinuevo [Espagne] ; Jordi Rumia [Espagne] ; Enric Ferrer [Espagne]

Source :

Movement disorders [ 0885-3185 ] ; 2002.

RBID : Pascal:02-0314469

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Stimulation instrumentale, Noyau sousthalamique, Bilatéral, Qualité vie, Traitement, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Aged, Bilateral, Dominance, Cerebral (physiology), Electric Stimulation Therapy, Female, Follow-Up Studies, Human, Humans, Instrumental stimulation, Male, Middle Aged, Neurologic Examination, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Parkinson disease, Quality of Life, Quality of life, Subthalamic Nucleus (physiopathology), Subthalamic nucleus, Treatment.
MESH :
- diagnosis : Parkinson Disease.
- physiology : Dominance, Cerebral.
- physiopathology : Parkinson Disease, Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Adult, Aged, Electric Stimulation Therapy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neurologic Examination, Quality of Life.

Abstract

We examined the impact of the subthalamic nuclei (STN) deep brain stimulation (DBS) on the health-related quality of life (QoL) of patients with advanced Parkinson's disease (PD). Seventeen consecutive patients with refractory motor fluctuations and dyskinesia were included in the study (mean age, 60.9 ± 7.7 years [range, 43-74 years]; disease duration, 16.4 ± 8.5 years [range, 7-38 years]; mean off-medication Hoehn and Yahr stage, 4.23 ± 0.66 [range, 2.5-5]). Each patient', assessment was carried out using common rating scales, following the Core Assessment Program for Intracerehral Transplantation (CAPIT) protocol. Dyskinesia and emotional state were evaluated through the Abnormal Involuntary Movement Scale (AIMS) and the Hospital Anxiety and Depression Scale (HAD). QoL was assessed by means of the Parkinson's Disease Questionnaire Spanish version (PDQ-39). Significant benefit was obtained in the motor manifestations and complications of disease, as well as in the functional state and mood (P < 0.001). Some QoL dimensions (mobility and activities of daily living) and the PDQ-39 Summary Index (PDQ-39SI) showed a significant improvement (P < 0.001). Benefit was modest (P < 0.05) for three other domains (emotional well-being, stigma, bodily discomfort) and nil for the rest. There was no correlation between the change obtained in the QoL (PDQ-39SI) and in the other variables. As measured by the PDQ-39, STN-DBS significantly improves important aspects of QoL in patients with advanced PD.

Affiliations:

Le document en format XML

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<author><name sortKey="Ferrer, Enric" sort="Ferrer, Enric" uniqKey="Ferrer E" first="Enric" last="Ferrer">Enric Ferrer</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
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<term>Electric Stimulation Therapy</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Human</term>
<term>Humans</term>
<term>Instrumental stimulation</term>
<term>Male</term>
<term>Middle Aged</term>
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<term>Parkinson Disease (physiopathology)</term>
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<term>Parkinson disease</term>
<term>Quality of Life</term>
<term>Quality of life</term>
<term>Subthalamic Nucleus (physiopathology)</term>
<term>Subthalamic nucleus</term>
<term>Treatment</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dominance, Cerebral</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
<term>Subthalamic Nucleus</term>
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<term>Follow-Up Studies</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en">We examined the impact of the subthalamic nuclei (STN) deep brain stimulation (DBS) on the health-related quality of life (QoL) of patients with advanced Parkinson's disease (PD). Seventeen consecutive patients with refractory motor fluctuations and dyskinesia were included in the study (mean age, 60.9 ± 7.7 years [range, 43-74 years]; disease duration, 16.4 ± 8.5 years [range, 7-38 years]; mean off-medication Hoehn and Yahr stage, 4.23 ± 0.66 [range, 2.5-5]). Each patient', assessment was carried out using common rating scales, following the Core Assessment Program for Intracerehral Transplantation (CAPIT) protocol. Dyskinesia and emotional state were evaluated through the Abnormal Involuntary Movement Scale (AIMS) and the Hospital Anxiety and Depression Scale (HAD). QoL was assessed by means of the Parkinson's Disease Questionnaire Spanish version (PDQ-39). Significant benefit was obtained in the motor manifestations and complications of disease, as well as in the functional state and mood (P < 0.001). Some QoL dimensions (mobility and activities of daily living) and the PDQ-39 Summary Index (PDQ-39SI) showed a significant improvement (P < 0.001). Benefit was modest (P < 0.05) for three other domains (emotional well-being, stigma, bodily discomfort) and nil for the rest. There was no correlation between the change obtained in the QoL (PDQ-39SI) and in the other variables. As measured by the PDQ-39, STN-DBS significantly improves important aspects of QoL in patients with advanced PD.</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Communauté de Madrid</li>
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<settlement><li>Madrid</li>
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<tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Martinez Martin, Pablo" sort="Martinez Martin, Pablo" uniqKey="Martinez Martin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name>
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<name sortKey="Ferrer, Enric" sort="Ferrer, Enric" uniqKey="Ferrer E" first="Enric" last="Ferrer">Enric Ferrer</name>
<name sortKey="Molinuevo, Jose Luis" sort="Molinuevo, Jose Luis" uniqKey="Molinuevo J" first="José Luis" last="Molinuevo">José Luis Molinuevo</name>
<name sortKey="Pilleri, Manuela" sort="Pilleri, Manuela" uniqKey="Pilleri M" first="Manuela" last="Pilleri">Manuela Pilleri</name>
<name sortKey="Rumia, Jordi" sort="Rumia, Jordi" uniqKey="Rumia J" first="Jordi" last="Rumia">Jordi Rumia</name>
<name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
<name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name>
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</record>

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Movement Disorders (revue)

Bilateral subthalamic nucleus stimulation and quality of life in advanced Parkinson's disease

Bilateral subthalamic nucleus stimulation and quality of life in advanced Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.